This systematic literature review investigated whether Acceptance and Commitment Therapy (ACT) intervention facilitates psychological adjustment and reduces psychological distress following a Traumatic Brain Injury (TBI) in adults. An extraction procedure yielded 12 studies published between 2005 and 2020, with a total of 444 adult subjects diagnosed with a TBI, or a TBI with co-occurring disorders. Across all 12 studies, different measuring tools to measure distress and psychological adjustment were used; however, results indicated ACT’s effectiveness in maximizing acceptance of circumstances through values by targeting avoidance with individuals diagnosed with a TBI. The results are promising, and ACT may be an alternative to medication-based treatments in assisting individuals with TBI and psychological disorders.