Open J Pharma Sci
Background: 1,2,4-Triazole and its derivatives are important group of heterocyclic compounds characterized by a five-membered ring of two carbons and three nitrogen atoms and exhibited good pharmacological profile. A new class of 3,4,5-substituted-1,2,4-triazole scaffolds was synthesized and screened for its antimicrobial and analgesic activity.
Results and discussion: The synthesized 3,4,5-substituted-1,2,4-triazole derivatives were confirmed by 13C/1H-NMR and IR spectral data and evaluated its antimicrobial and analgesic activity. The synthesized derivatives showed good antimicrobial potential against Gram positive and Gram negative bacterial and fungal strains by tube dilution technique and analgesic activity by Tail immersion and Acetic acid induced writhing method and compared with standard drugs.
Conclusion: Especially compounds TA-11, TA-20 and TA-26 displayed more antimicrobial activity than standard drugs (cefadroxil (antibacterial) and fluconazole (antifungal) due to presence of electron withdrawing group. The compounds TA-13, TA-15 and TA-2, TA-15 exhibited good analgesic activity by Tail immersion and Acetic acid induced writhing method respectively due to presence of electron withdrawing group.