Online First

2021 : Volume 1, Issue 1

Comparative Study between Biodegradable-Polymer-Stentsand Standard Drug Eluting Stents in Diabetic Patients Presented with Acute Coronary Syndrome (ACS)

Author(s) s: Ehab Elhefny, 1 Layth Mimish, 2 Samy Nouh 1 and Ahmed Nada 2

1 Department of Cardiology , Al-Alzhar University , Egypt

2 Department of Cardiology , King Abdul-Aziz University , Saudi arabia

J Clin Cardiol Cardiovasc Res

Article Type : Research Article

Background: It has been suggested that the persistence of polymeric coating of drug-eluting stents provokes delayed arterial healing and as well as a cascade of cellular and biochemical events that cause patho-physiological processes such as release of cytokines which trigger the proliferation of smooth muscle cells, block the endothelialization of the nearby tissue, and induce other side-effects such as late andvery late stent thrombosis.

Aim: The primary aim of our prospective study was tocompare between the uses of BDP-DES and DP-DES in diabetic patients presented with ACS, regarding stent thrombosis, ISR and MACE during 12 months clinical followup and follow up coronary angiography in 6-12 months postACS index admission as well.

Methods: Our study enrolled 100 diabetic patients presentedto the Emergency department at King Abdul-Aziz university hospital as a case of ACS who were candidate for coronary angiography with PTCA and stenting.

Patients were divided into 2 groups according to the deployed stent:

Group A (BP-DES: 50 cases)
Group B (DP-DES: 50 cases)


Inclusion criteria: All patients post-Acute Coronary Syndromewho have DM and underwent for coronary angiography with PTCA and stenting.


Exclusion criteria: 1-Non diabetic patients. 2- known IschemicHeart Disease (IHD) or previous coronary intervention (PCI). 3- Pregnancy. 4- Allergy or contraindication to Aspirinand Plavix.

Results: There was no statistically significant difference as regard typical/atypical anginal symptoms in both groups in the 12 months follow up after the procedure.

Also, there was no statistically significant difference between the incidence of ISR, stent diameter (p=0.791) and stent length (p=0.952) in both groups. The mean diameter and length ± SD in the BDP-DES group and the PP-DES group were (2.82 ± 0.39 and 2.88 ± 0.43), and (26.2 ± 11.9 and 30.1± 13.1) respectively.

ISR was 10% in biodegradable polymer DES group and 12% in durable polymer DES group and it wasn’t significant statistically (p=0.719).

There were no reported cases of stent thrombosis in both groups.

Conclusion: BDP-DES, when compared to DP-DES, in diabetic patients presenting with ACS, showed no statistically significant difference and the outcomes were comparable between both the groups.

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