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2021 : Volume 1, Issue 1

Assessing Agreement of Transcutaneous Carbon Dioxide Monitoring and Blood Gas Analysis in a Neonatal Population

Author(s) s: Mia Kahvo, 1 Ajit Mahaveer 2 and Ranganath Ranganna 2

1 Regional Newborn Intensive Care Unit , St Michael's Hospital , England

2 Newborn Intensive Care Unit , St Mary's Hospital , England

Open J Pediatr Neonatol

Article Type : Research Article


Objective: To assess agreement between transcutaneous carbon dioxide (TcCO2) monitoring and blood gas analysis in neonates.

Study Design: This was a prospective observational study performed in a tertiary neonatal intensive care unit. 19 infants with a mean postmenstrual age of 35+3 weeks were included. Agreement was assessed by Bland-Altman analysis and concordance correlation coefficient. End-user feedback was collected from staff and infants were assessed for evidence of skin damage.

Results: Overall bias from 698 paired samples was -0.30 (SD 1.21, p<0.0001) with good concordance (CCC 0.80). 69% (95% CI 65%-72%, p=0.0003) of samples fell within the predefined clinically acceptable difference of 1kPa. Agreement was more favorable for non-invasively ventilated infants (bias -0.11, CCC 0.91). Staff feedback was positive, and no infants suffered skin damage.

Conclusion: TcCO2 monitoring is a reliable assessment tool for both invasively and non-invasively ventilated neonates. It can be used as an adjunct to blood gas analysis, reducing the frequency of invasive blood tests.

Keywords: Neonate; Transcutaneous Monitoring; Rspiration; Blood Gas Analysis

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