Human Adipose Tissue-Derived Mesenchymal Stem Cells Alleviate Atopic Dermatitis via Decreased Serum Level of IgE and Number of Mast Cells

Current Issues

2021 : Volume 1, Issue 1

Author(s) s: Yeganeh Davoudi, ¹ Minoo Mahmoodi, ¹ Masoud Ghorbani, ² Mohammad Ali Nilforoushzade ³ ⁴ and Rahim Ahmadi ¹

¹ Department of Biology , Islamic Azad University , Iran

² Department of Research and Development , Pasteur Institute of Iran , Iran

³ , Jordan Dermatology and Hair Transplantation Center , Iran

⁴ Skin and Stem Cell Research Center , Tehran University of Medical Sciences , Iran

Open J Pharma Sci

Article Type : Research Article

Atopic dermatitis (AD) is a major inflammatory skin disease. Most patients with atopic dermatitis have elevated serum levels of mast cells and IgE. Mesenchymal stem cell (MSC) has been applied for the therapy of allergic disorders due to its beneficial immunomodulatory abilities. We sought to investigate the safety and the efficacy of human adipose tissue-derived MSCs (hAT-MSCs) in mouse atopic dermatitis (AD) model and to determine the serum levels of mast cells (MC) and IgE after subcutaneous administration.