Pleural effusion is a type of respiratory disease which is caused due to collection of fluid between the lung and the chest wall in the pleural space. The fluid accumulated by variety of reasons, including pneumonia, cancer or congestive heart failure. Excess fluid impairs breathing by limiting the expansion of lungs. Pleural effusion is of different types depending on the nature of fluid and its entry into pleural space, they include hemothorax (blood), hydrothorax (serous fluid), urinothorax (urine), pyothorax (pus), chylothorax (chyle) etc. Symptoms of pleural effusion include Liver cirrhosis, severe hypoalbuminemia, nephrotic syndrome, acute atelectasis, myxedema, peritoneal dialysis, Meigs's syndrome, chest discomfort and shortness of breath. The disease is diagnosed by physical examination and chest X-ray. If the accumulated fluid is more than 300 mL, clinical signs such as dullness to percussion over the fluid, decreased movement on the affected area of chest, breath sounds, decreased vocal resonance and fremitus are detected. Thoracentesis a clogged chest tube in the setting of continued production of fluid will result in residual fluid left behind when the chest tube is removed. The fluid lead to complications like hypoxia or fibrothorax if scarring occurs. Repeated effusions may require chemicals like talc, bleomycin, tetracycline, doxycycline and in severe cases surgical procedures like pleurodesis, pleurodesis, pleural decortication are recommended.